Chromosomal analysis for Repeated Pregnancy Loss & Infertility

Why couple experiencing fertility problem or difficulty conceiving should undergo chromosomal analysis?

Unfortunately, 25 percent of clinical pregnancies end in miscarriage, with first-trimester pregnancy losses being the most frequent. In women receiving therapy for assisted reproduction, the percentage of chromosomally defective patients rises above 60%

Each of the 46 chromosomes, made up of 23 pairs, must be present in two copies in each fetal cell, one from the mother's egg and the other from the father's sperm. A miscarriage may be caused by chromosomal abnormalities brought on by an inappropriate number of chromosomes.

Chromosome analysis sometimes referred to as genetic karyotyping, is a technique that may identify certain genetic anomalies. A genetic ailment or disease may be confirmed or identified using it. A couple may also be at risk of having a child with a genetic or chromosomal abnormality, according to the results of the tests. If: Your doctor could advise genetic karyotyping.

• You've been trying to become pregnant for almost a year now.
• You've had two or more repeated miscarriages.
• You've had a stillbirth.
• The male partner's sperm count is either zero or very low. (Also known as severe oligozoospermia or azoospermia.)
• Primary ovarian dysfunction has been proven to exist in the female spouse. (Also known as premature ovarian failure or POI, primary ovarian insufficiency.)

Before using assisted reproductive technologies, such as IUI or IVF, genetic karyotyping can be necessary. This is particularly true for people thinking about IVF with ICSI since it raises the risk of transferring genetic abnormalities and male infertility.

Chromosomal analysis procedure

In cases of infertility in couples, the diagnostic procedure often entails drawing blood from both partners. The blood samples are brought to a laboratory, where they are analyzed

Cells taken from the blood specimen are then put in a specialized dish to stimulate their growth. After the cells have developed to a certain point, they are dyed so that they can be analyzed more closely under a microscope.

The lab technician performs a size and shapes analysis of the cells. In addition, a snapshot of the cells is taken, and the total number of chromosomes inside each cell is tallied. An analysis of the chromosomal layouts may be performed using the specialist image.

Chromosomal analysis for Repeated Pregnancy Loss & Infertility is to find out the possibility for:

• Klinefelter syndrome
• Y Chromosome Micro-deletions
• Balanced translocation
• Kallmann syndrome:
• CFTR gene mutation
• Risk of passing on a genetic condition

What options are available if the couple's chromosomal analysis has a high congenital risk?

What hereditary risks you are exposed to will determine your alternatives. The identification of a genetic issue or risk may, in some circumstances, confirm or assist in the diagnostic test of a particular type of infertility, increase your chances of pregnancy loss or stillbirth, and raise your risk of possessing a child with a particular genetic defect, and boost the chance of passing on infertility to your baby.

Your findings should be discussed with a genetic counsellor. Typically, you have the following alternatives available to you:

• Do nothing and let nature run its course.
• Select preimplantation genetic testing.
• Choose prenatal diagnosis.
• Select a sperm donor, an egg donor, or an embryo donor.
• Adopt a kid or lead a childless lifespan.